Cell Cycle Inhibitors Therapeutics Pipeline Analysis

Cell cycle inhibitors include cyclin inhibitors and cyclin-dependent kinases (CDKs), which plays major role in developing new class of anti-cancer therapies. Also, cell cycle inhibitors in combination with chemotherapy, overcome drug resistance and improve cytotoxic efficacy. CDKs are rational targets for cancer treatment, that could restore cell-cycle checkpoints and may induce apoptosis.

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Tolero Pharmaceuticals, Inc., a clinical-stage company focused on developing novel therapeutics for hematologic and oncologic disorders, developing alvocidib – a potent CDK9 inhibitor in combination with cytarabine and daunorubicin. In April 2018, the company presented preclinical data supporting the apoptosis-inducing activity of alvocidib at the American Association for Cancer Research (AACR) Annual Meeting in the U.S., Chicago.

Boehringer Ingelheim International GmbH is in the process of developing volasertib, a cell-cycle kinase inhibitor by acting as a polo-like kinase 1 (PLK1) antagonist for the treatment of AML. ImmunoGen Inc., Pharma Mar S.A., and Eli Lilly and Company are some other major companies involved in the development of cell cycle inhibitor therapeutics for the management of several diseases.

The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with detailed analysis of pipeline and clinical trials. Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licencing, grants, technology and others.

Interleukin Receptor Modulators Therapeutics – Pipeline Analysis 2019

Interleukin receptors are a group of cytokine receptors that are expressed by leukocytes. Interleukin receptors play an important role in the functioning of the immune system. However, with complete knowledge of their role in pathogenesis of different diseases from allergic reactions to autoimmune disorders and even cancer makes these interleukin receptors an attractive target among different available treatment modalities.

Immune-modulatory role of interleukins as well as their direct and indirect contact with apoptosis and other cancer developments, angiogenesis and progression pathways makes them attractive targets for cancer treatment. GlaxoSmithKline plc is in the process of developing GSK2618960 as an interleukin 7 modulator for the treatment of Sjogren’s syndrome. Some of the other companies having pipeline of interleukin receptor modulators include Can-Fite BioPharma Ltd., and Pfizer Inc.

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Pipeline Analysis of Endothelin Antagonists Therapeutics

Endothelin antagonists are drug candidates that acts against endothelin receptors and generate pharmacological actions such as blocking the vasoconstriction and mediate vasodilatation. Endothelin-1 is a peptide which is comprised of 21 amino acids and formed by vascular endothelium.

The biological molecule is a potent vasoconstrictor that binds to endothelin receptors A and B. This further leads to the activation of IP3 DA pathway that causes efflux of calcium ions from the endoplasmic reticulum and produce vasoconstriction in the smooth muscles. The endothelin receptor B release nitric oxide that produce vasodilation effect in erectile muscles. The endothelin-1 releases calcium in heart, resulting in the increment of cardiac rate. The endothelin receptor antagonist is having powerful vasodilation properties as they have been shown to improve the hemodynamic and decrease the mortality rate in the mouse models of heart failure.

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AbbVie Inc. is in the process of developing ABT-627 as an endothelin receptor antagonist for the treatment of diabetic nephropathy in type 2 diabetes. Idorsia Pharmaceuticals Ltd. is developing ACT-132577 as an endothelin receptor antagonist for the treatment of resistant hypertension. Moreover, Retrophin Inc. is also developing sparsentan as an endothelin receptor antagonist for the treatment of focal segmental glomerulosclerosis. Ligand Pharmaceuticals Inc., and ENB Therapeutics LLC are some other companies having pipeline of endothelin receptor antagonist.