Category: Epidermal growth factor receptors

Mitogen-Activated Protein Kinase (MAPK) Inhibitors Therapeutics Pipeline analysis

Mitogen-activated protein kinase (MAPK) are ubiquitous regulators of many cellular functions including cell proliferation, cellular growth, inflammatory responses to stress signals and cell differentiation. MAPK pathway, involves three main kinases, Raf, MEK and ERK, has emerged as a novel target for the development of new cancer therapies with reduced side-effects.

MAPK inhibitors are being developed as small molecules, for the treatment of various types of cancer. They have also showed additional benefits with high effectiveness at lower concentrations in comparison to the ATP-competitive inhibitors, for the cancer therapy.

Mereo BioPharma Group plc is in the process of developing Acumapimod as an oral p38 MAPK inhibitor for the treatment of acute exacerbations of chronic obstructive pulmonary disease (AECOPD). eFFECTOR Therapeutics Inc., Genentech Inc., and Kura Oncology Inc. are some other companies having pipeline of MAPK inhibitors.

For more info about Mitogen-Activated Protein Kinase (MAPK) Inhibitors Therapeutics Get the sample report at: https://www.pharmaproff.com/request-sample/1206

Epidermal Growth Factor Receptor (EGFR) Antagonists Therapeutics – Pipeline Analysis 2019

Epidermal growth factor receptors (EGFR) are a group of receptor tyrosine kinase (RTK) that plays a major role in cell proliferation, survival and differentiation. In most of the cancer, EGFR are amplified and overexpressed, due to dysregulation, resulting in cancer development.

Download the sample report @ https://www.pharmaproff.com/request-sample/1208

EGFR inhibitors therapies have shown improvement by inhibiting receptor signalling and enhancing the effects of radiation therapy and conventional chemotherapy with their anti-tumor activity. Cetuximab, Panitumumab, Erlotinib and Afatinib are some of the major marketed drugs as anti-EGFR therapies for the treatment of colorectal cancer, head and neck cancer and non-small cell lung cancer.

Get the detailed analysis @ https://www.pharmaproff.com/report/egfr-antagonists-therapeutics

Daiichi Sankyo Co., Ltd. is in the process of developing Nimotuzumab as a humanized monoclonal antibody which acts as an EGFR inhibitor for the treatment of gastric cancer. Some of the other companies having pipeline of EGFR inhibitors include Daiichi Sankyo Co., Ltd., Shionogi & Co. Ltd., AstraZeneca PLC, and Amgen Inc.

The report provides a comprehensive understanding of the pipeline activities covering all drug candidates under various stages of development, with detailed analysis of pipeline and clinical trials. Pipeline analysis of drugs by phases includes product description and development activities including information about clinical results, designations, collaborations, licencing, grants, technology and others.